All federal, state and local laws prohibiting the manufacture, sales, possession and use of any mind-altering and or addictive drugs are absolutely unconstitutional. There just is no such enumerated power. The Intestate Commerce Clause and the necessary and proper clause of the US Constitution does not save the federal government here. While the Constitution gives the federal government the power to "regulate" commerce, it does not give it the power to prohibit the manufacture, sales or use of certain substances or products, just because said substances or products may harm the user.
The author is a little shrill, and the arguments on the constitutionality of the states' ability to regulate drugs are very thin. As well, he really neglects to address the topic of his title. However, he makes a couple of good points, especially on the schizophrenic nature of our drug laws and the slippery slope of government protecting us from ourselves.